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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FIGN All Species: 9.09
Human Site: S251 Identified Species: 13.33
UniProt: Q5HY92 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5HY92 NP_060556.2 759 82146 S251 S Y S Y P S A S Y P P Q T A V
Chimpanzee Pan troglodytes XP_001153855 674 74011 M192 L R N A Q P P M V T N T A R T
Rhesus Macaque Macaca mulatta XP_001097992 759 82110 S251 S Y S Y P S A S Y P P Q T A V
Dog Lupus familis XP_545496 695 74019 H213 G Y N G S Y L H S A Y G S Q P
Cat Felis silvestris
Mouse Mus musculus Q9ERZ6 759 82080 S251 S Y S Y P S A S Y P P Q T A V
Rat Rattus norvegicus Q6GX84 677 74178 A195 Q S T L F P M A T N T K T C L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506217 731 78137 G248 G A R S R P D G L P L D E R P
Chicken Gallus gallus Q5ZK92 613 66247 D131 I S M A L R I D E D E R A G Q
Frog Xenopus laevis Q6DDU8 655 72133 D172 V P H A A S S D C Q I P E G S
Zebra Danio Brachydanio rerio Q503S1 736 79183 P247 P V A P G Y S P G G A P P P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQN8 523 58530 C41 H H A R L Q A C E S M E K A M
Honey Bee Apis mellifera XP_625184 585 66969 W103 I E N I I N T W K N K E I V I
Nematode Worm Caenorhab. elegans O16299 594 66169 G112 L K S R P F L G E K S S F K L
Sea Urchin Strong. purpuratus XP_783737 603 65189 G121 G T N R K V L G V T R R A P N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 I41 F D G A I A Q I N K H L N T L
Baker's Yeast Sacchar. cerevisiae P39955 897 100313 L342 T A P A L P S L P P P P L L N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 37.6 99.4 72.9 N.A. 97.8 35.5 N.A. 31.6 24.8 35.7 71.2 N.A. 25.2 26.6 26.4 30.8
Protein Similarity: 100 54.9 99.4 79.1 N.A. 99.3 54.9 N.A. 47 42.2 53.4 83.7 N.A. 40.8 46.6 43.3 46.9
P-Site Identity: 100 0 100 6.6 N.A. 100 6.6 N.A. 6.6 0 6.6 0 N.A. 13.3 0 13.3 0
P-Site Similarity: 100 6.6 100 20 N.A. 100 33.3 N.A. 6.6 6.6 13.3 13.3 N.A. 40 26.6 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. 23.9 25 N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 40.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 13 32 7 7 25 7 0 7 7 0 19 25 0 % A
% Cys: 0 0 0 0 0 0 0 7 7 0 0 0 0 7 0 % C
% Asp: 0 7 0 0 0 0 7 13 0 7 0 7 0 0 0 % D
% Glu: 0 7 0 0 0 0 0 0 19 0 7 13 13 0 0 % E
% Phe: 7 0 0 0 7 7 0 0 0 0 0 0 7 0 0 % F
% Gly: 19 0 7 7 7 0 0 19 7 7 0 7 0 13 0 % G
% His: 7 7 7 0 0 0 0 7 0 0 7 0 0 0 0 % H
% Ile: 13 0 0 7 13 0 7 7 0 0 7 0 7 0 7 % I
% Lys: 0 7 0 0 7 0 0 0 7 13 7 7 7 7 0 % K
% Leu: 13 0 0 7 19 0 19 7 7 0 7 7 7 7 19 % L
% Met: 0 0 7 0 0 0 7 7 0 0 7 0 0 0 7 % M
% Asn: 0 0 25 0 0 7 0 0 7 13 7 0 7 0 13 % N
% Pro: 7 7 7 7 25 25 7 7 7 32 25 19 7 13 13 % P
% Gln: 7 0 0 0 7 7 7 0 0 7 0 19 0 7 7 % Q
% Arg: 0 7 7 19 7 7 0 0 0 0 7 13 0 13 0 % R
% Ser: 19 13 25 7 7 25 19 19 7 7 7 7 7 0 13 % S
% Thr: 7 7 7 0 0 0 7 0 7 13 7 7 25 7 7 % T
% Val: 7 7 0 0 0 7 0 0 13 0 0 0 0 7 19 % V
% Trp: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % W
% Tyr: 0 25 0 19 0 13 0 0 19 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _